Paper digest: Coalescent with reassortment

Bayesian inference of reassortment networks reveals fitness benefits of reassortment in human influenza viruses by Muller et al. on PNAS, 2020.

Joint Inference of Migration and Reassortment Patterns for Viruses with Segmented Genomes by Ugnė Stolz, Tanja Stadler, Nicola F Müller, and Timothy G Vaughan on Molecular Biology and Evolution, 2021.

• This paper is about Structured Coalescent with Reassortment (SCORE).
• This work was built upon the previous work of Müller et al. 2020, which is the unstructured coalescent with reassortment model.
• Reassortment is well known in influenza viruses. Reassortment events have clear boundaries in the genome, in comparison to recombination.
• Intuitively, migration and reassortment are closely related, as reassortment can only occur when two different strains co-infect the same host.

Methods